Bioinformatics : Methods And Applications (Genomics, Proteomics And Drug Discovery)

Designed as a text for students and professionals pursuing careers in the fields of molecular biology, pharmacy and bioinformatics, the fourth edition continues to offer a fascinating and authoritative treatment of the entire spectrum of bioinformatics, covering a wide range of high-throughput technologies. In this edition, four new chapters are included and two chapters are updated.

As a student-friendly text, it embodies several pedagogic features such as detailed examples, chapter-end problems, numerous tables, a large number of diagrams, flow charts, a comprehensive glossary and an up-to-date bibliography. This book should prove an invaluable asset to students and researchers in the fields of bioinformatics, biotechnology, computer-aided drug design, information technology, medical diagnostics, molecular biology and pharmaceutical industry.

1. Bioinformatics: An Introduction

2. Introduction to Biological Database

3. Information Search and Data Retrieval

4. Genome Analysis and Gene Mapping

5. Alignment of Pairs of Sequences

6. Alignment of Multiple Sequences and Phylogenetic Analysis

7. Introduction to Phylogenetics

8. Methods of Phylogenetric Analysis

9. Tools for Similarity Search and Sequence Alignment

10. Profiles and Hidden Markov Models

11. Gene Identification and Prediction

12. RNA Structure Prediction

13. Gene Expression and Microarrays

14. Protein Classification and Structure Visualization

15. Protein Structure Prediction

16. Proteomics

17. Computational Methods for Pathways and Systems Biology

18. Introduction to Drug Discovery

19. Drug Discovery: Technology and Strategies

20. Cell Cycle: Key to Drug Discovery

21. Structural Biology and Virtual Screening for Drug Discovery

22. Emerging Role of Biomarkers in Drug Development  

23. G-Protein Coupled Receptors as Drug Targets 

24. Ion Channels and Aquaporins as Potential Drug Targets  

25. Computer-aided Drug Design